There is increasing evidence that many complex disorfers (Table 1) collectively affect more than 30% of the population. These disorders involve neurovascular inflammation orchestrated by the unique tissue immune cell, the mast cell, which is critical in allergies but also in inflammation and regulates the permeability of the blood-brain barrier allowing the entry into the brain of substances that activate the brain defenders, microglia.  These conditions affect multiple organ systems and are often comorbid in the same patients.  As a result, diagnosis is difficult, and patients usually visit as many as ten different specialists over as many years before proper diagnosis is made.  Given that there is no effective treatment for these conditions, health providers prescribe on average two drugs or supplements per condition, with the risk of 25% adverse reactions (ADRs) for every two such treatments. ADRs are estimated to account for up to 30% of all hospital admissions in the USA, and up to 40% of ADRs are estimated to be fatal among children. Yet, there are hardly any biomedical scientists knowledgeable and able to address patients with complex neurovascular inflammatory disorders.

Our BiomedAdviceTM consultation includes reviewing records, analyzing the data and referring individuals to the best appropriate clinical centers for proper investigation and treatment.
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Moreover, BiomedAdviceTM services include working with companies, foundations and institutions to help introduce appropriate services, develop unique diagnostic panels, and design novel treatment approaches for such complex conditions.  

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